Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food.
نویسندگان
چکیده
The dopamine receptor blocker pimozide attenuated lever-pressing and running for food reward in hungry rats. In each case the characteristic behavior of pimozide-treated rats was the same as that of undrugged rats when reward was simply withheld. Drug-induced performance difficulties were ruled out by the presence of periods of normal responding in drug-treated animals. Pimozide appears to selectively blunt the rewarding impact of food and other hedonic stimuli.
منابع مشابه
Pimozide-induced suppression of responding: evidence against a block of food reward.
MASON, S. T., R. J. BENINGER, H. C. FIBIGER AND A. G. PHILLIPS. Pimozide-induced suppression of responding: Evidence against a block of food reward. PHARMAC. BIOCHEM. BEHAV. 12(6) 917-923, 1980.--Male albino rats injected with 0.5 or 1.0 mg/kg pimozide showed a decline in the rate of lever pressing on a continuously reinforced schedule for food reward. A similar decline was seen when responding...
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ورودعنوان ژورنال:
- Science
دوره 201 4352 شماره
صفحات -
تاریخ انتشار 1978